Revise Biochemistry for your FMGE 2023 with Kings
Kings International Medical Academy has established itself as a premier coaching centre for FMGE, consistently delivering remarkable results. Our exceptional achievements in FMGE reflect our unwavering commitment to excellence. It is our privilege to have Dr. V.S. Kumar, a highly esteemed faculty member, deliver a captivating lecture on Biochemistry at Kings International Medical Academy. Today, let's explore the intriguing subject of "De novo fatty acid synthesis."
DE NOVO FATTY ACID SYNTHESIS
Step 1- Transport of “2c” unit
Step 2- Canboxylation of Acetyl CoA → Malonyl CoA
Step 3- Action of FA Synthase & Elongation of chain
Source:
Aerobic glycolysis (PDH complex)
-Fatty acid oxidation in Mitochondria
Step 1:
Step 2:
Acetyl-CoA → Malonyl CoA
Acetyl-CoA Carboxylase
A-ATP
B-Biotin (B7) – Cofactor
C- CO₂
Step 3:
Malonyl-CoA
FA Synthase Complex
1) Ketoacyl synthase
2) Ketoacyl reductase
3) Enoyl reductase
4) Hydrafase
5) Malonyl-acetyl Acetyl transferase
6) Thioesterase (deacylase)
FA-synthase – lactating mammary gland
→10 C- Capric acid 12 C- Lauric acid
FA-oxydation:
6 types
Major principle- B-oxidation
- M.c. type
- Organelle- mitochondria
- Organs- liver, A.tissue & muscle
3 types:
Step 1 – Activation of FA
Step 2 – Transport of activated FA into Mitochondria
Step 3 - B-OX reactions